Monday, December 7, 2020

The DOD Plan to help save the human race.

 

Special edition of the Jones Report:
  
This purpose of this post is to describe a key goal of the USA Department of Defense (DOD) that is now obvious to this observer:
 
To Prevent Future (more deadly) Pandemics and even Human Extinction. 
 
A BBC report  sums up the matter as follows...
 
 "Long-dormant bacteria and viruses, trapped in ice and permafrost for centuries, are reviving as Earth's climate warms
 
However, what would happen if we were suddenly exposed to deadly bacteria and viruses that have been absent for thousands of years, or that we have never met before?

We may be about to find out. Climate change is melting permafrost soils that have been frozen for thousands of years, and as the soils melt they are releasing ancient viruses and bacteria that, having lain dormant, are springing back to life."

http://www.bbc.com/earth/story/20170504-there-are-diseases-hidden-in-ice-and-they-are-waking-up 

"Neanderthals were very early (archaic) humans who lived in Europe and Western Asia from about 400,000 years ago until they became extinct about 40,000 years ago. Denisovans are another population of early humans who lived in Asia and were distantly related to Neanderthals."
 
What made the Neanderthals and Denisovans  extinct after over 300,000 years as successful inhabitants of earth?  Scientists do not fully know.  Could it have been a pathogenic virus, about 30,000 years ago, that spread and overtook their immune system to mass extinction?
 
 Fleeing a Mammoth
 
It was likely a combination of factors, however a pandemic caused by a microscopic pathogen cannot be ruled out.
 
The world is currently experiencing the Covid 19 (C19) pandemic. Be it either developed or a natural mutation in bats, the C19 virus has an accumulated 1.52 million worldwide deaths and counting.  The C19 virus is not a mass-extinction pandemic.  The combination of natural immunity, man-made vaccines, antibodies and herd immunity removes mass extinction as likely possibility from the current pandemic.

However, viral pathogens mutate and without intervention by creation of rapid vaccine production it is plausible that a deadly virus could yet naturally mutate that has potential to wipe out mankind.

What prehistoric pathogens lurk below melting glaciers  and frozen tundras leak from beneath and can populate within wildlife and then to man?  As northern most locales become more accessible for mining, the possibility of unwittingly bringing up long buried unknown pathogens  from millions of years ago increases.

 
"Global warming has various effects on human health. The main indirect effects are on infectious diseases. Although the effects on infectious diseases will be detected worldwide, the degree and types of the effect are different, depending on the location of the respective countries and socio-economical situations."
 
At no time in prior earth history has the likelihood of even more serious pandemics and even human extinction been higher by a yet unknown pathogen surfacing or from a biological mishap in a laboratory by "curious" scientists or biological warfare.
 
As the recent world wide C19 pandemic events unfolded, the rapid development, with support from Operation Warp Speed (OWS),  of mRNA vaccines by Pfizer and Moderna will be distributed as soon as the super-cooled vaccines can be manufactured and transported and shipped and then administered in a lengthy time consuming process.
  
The next pathogen may be much more efficient at spreading.  The DOD is taking steps to address the danger.  Every pathogen has a DNA genetic sequence that once cracked can be implanted with just the code of the antigen into a plasmid such that the immune system becomes trained to recognize the foreign invader and illicit a natural antibody and targeted T cell response. This is a DNA vaccine.

The messenger RNA vaccines for C19 by Pfizer and moderna use a messenger RNA process that will produce antibodies for a limited time. Thus far, it is not known for how long.  The the durability of such vaccines regarding the length of antibody protection is in question as well as the longer lasting T cell protective response. While mRNA vaccines have yet to be used in the market, early testing for at least four infectious diseases: rabies, influenza, cytomegalovirus, and Zika experiments have been done.

Biologically,  mRNA is transcribed from DNA and travels into a cell's cytoplasm where it's translated by ribosomes into proteins.
 
Conversely,  Inovio's DNA vaccine is applied such  that the DNA itself creates a balanced mRNA response to in-turn respond with balanced neutralizing antibodies and targeted T cells from the immune system.  In theory, and in practice, Inovio's MERS and Ebola vaccines are proven.

The Walter Reed Army Institute of Research Clinical Trials Center tested the DNA vaccine with Inovio Pharmaceuticals against another SARS virus similar to Covid 19 - the  Middle East Respiratory Syndrome (MERS).  The "vaccine was well tolerated with no major side effects reported by the volunteers. More than 85 percent of volunteers exhibited a detectable immune response to MERS-CoV after just two vaccinations. This immune response persisted throughout the study and was similar in magnitude to the response seen in survivors of natural MERS-CoV infection."
 
 
 
While the FDA and OWS team has given companies with mRNA vaccines special privileges to accelerate development, the DOD is well aware that a more rapid, easier handling vaccine process is needed to respond to the next pathogen that can be even more deadly and rapid than Covid 19.
 
From prior partnership, the Pentagon is well aware that one small biotech company, Inovio Pharmaceuticals, is on the cutting edge of working towards bringing DNA vaccines and treatments for not just C19 but various deadly cancers and other diseases such as RRP.
 

The DoD is currently sponsoring Inovio in the  recently continued Phase 2/3 FDA clinical trial evaluating INO4800 against Covid 19.
 
So many want to know why did the FDA temporarily  stop the INO4800 trial  with such a critical need to resolve the Covid19 pandemic?
 
The answer may be:
 
America has a higher goal in sight than " just beating Corona".   To that goal certain milestones must be met.
 
The way a DNA vaccine is delivered is important to gaining effectiveness.  Inovio's patented device called "Cellectra" has been used in several past and ongoing  trials.  Amidst the widely touted Billion dollar Pharma contracts to big Pharma by OWS, the Pentagon quietly awarded Inovio a $ 71 Million contract to develop and deliver advanced Cellectras to the DoD.  
 
Meanwhile, The FDA had questions on the transfer of use into the newer models.  The hold on the clinical trial has been lifted and use of the existing Cellectra2000.  There is concurrent validation on-going to assure that the  newer more adaptable model delivers an equivalent safe and effective dose of vaccine.
 
In addition, "the Department of Defense (DOD) awarded Ology Bioservices and Inovio a contract valued at $11.9 million to partner to rapidly manufacture a COVID-19 DNA vaccine. This work is supported by the Office of the Assistant Secretary of Defense for Health Affairs with funding from the Defense Health Agency."
 
Conclusion
 
It is now abundantly clear that the facts point to DOD resources being applied to defend the US military against pathogens that include  Covid 19, but importantly, more deadly future pathogens.   It extends into preparation for a future pathogen that immediately requires a rapid process that can be trusted to create fast and more easily transported, stored and administered  protective vaccines. The Pentagon efforts with scientists from the US government and Inovio Pharmaceuticals are surging ahead to meet the challenge.  A key point is that data seems to show that more naturally balanced antibodies and longer lasting T cell immunity may prevail in the DNA vaccine with better safety and effectiveness than current mRNA vaccines offer.  America is not just working  to be better  prepared to protect the military in such confined places as Naval ships and submarines and at bases around the world. 
 
History shows that America is about more than itself.  Just  as America helped save the world from tyranny in WW2, the key outcome goal is for America to be better prepared to help save the entire human race (in all countries) from deadly pathogens surfacing from glaciers, frozen tundra melts, biological warfare threats as well as natural viral mutations.  

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