
Market Talk
Stock Talk
Speculation Corner — ONCY (and BMS?)
ONCY just shifted gears with the FDA’s alignment on its Phase 3 pancreatic trial. The design is agreed to, and Pelareorep’s cancer-lysing and immune-activating profile is now in front of regulators — a milestone that finally puts real structure behind the PDAC program.
The bigger angle? The checkpoint players. Keytruda has been everywhere, but checkpoints still struggle in cold-tumor settings like pancreatic, ovarian, and several other solid cancers where ALL the checkpoints usually fail. Opdivo (BMS) is in the same situation — results and sales in these tough cancers have been slower than hoped. If Merck drags its feet, BMS is known to move faster when a new drug can make their checkpoint work in places it normally falls flat. Pelareorep is that kind of immune primer — the piece that turns a “cold” tumor into something a checkpoint can actually attack.
And this is where the story gets bigger. When a small biotech holds something that could strengthen multiple big-pharma checkpoint franchises, you’re not just looking at partnership potential — maybe even buyout potential starts creeping in. Big pharma doesn’t like watching competitors gain the upper hand in cancers they’ve been failing to crack for years. ONCY — it’s a company to watch closely. Here at the Jones Report, we use the word maybe on speculation — maybe some.
Ramaco Resources struggles in a coal mindset
Ramaco Resources with it's METC and METCB has been pushed back into the coal bucket by the market, despite the rare-earth potential sitting under the Brook Mine. The stock is acting like a pure coal play and is being priced that way. The rare-earth story hasn’t clicked with investors because Washington hasn’t moved, the defense sector hasn’t leaned in publicly, and investors don’t reward “potential” without partners or independently verified assays that change the narrative. Until that happens, Ramaco trades like a dog and gets valued like one. The long-term rare-earth opportunity may still be real, but for now it sits in the background rather than driving the stock.
Staying Nimble
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More later so ....Stay tuned, if you dare!
For now, we close by noting that any view on the market and stocks on any particular day may change in the days to come. That is why we watch and see how our views match up with reality. Looking ahead a few months may be a way to do things - but thinking too deeply about world events and the recent alliances forming, can make projecting ahead a dicey endeavor.
All in all - we use the word maybe "some", not "too much" and play it accordingly. Never get arrogant in our notions because things do change - and individual stocks are subject to many factors outside our control. So, we try to -stay aware.
With all the above caveats and attempted prognostications, I will close this post. Stay tuned for more opining on the market and stocks to watch.
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